It isn't so much the knock as the power loss in surges. The longer it runs the worse it gets. At first only wide open throttle, then at any throttle setting. I have the same motor and ESC combination in another plane that works perfectly.
How much trouble to get to the other ESC that you are using on the one running right? I'd grab it and plug it up and give it a try, eliminate the ESC from being the culprit.Xoar 20x10. Shouldn't be a torque issue. The motor should be able to swing a 21x8 no problem.
@Xpress when you say losing sync, is that timing? I've heard them click, squeal, make all kinds of noises.