I should say that the twins have better torque in the lower RPM range to be more accurate, hence the spool up and ability to use a bigger prop. The single produces more power, just at higher RPM ranges.
My PTE-72 will turn the Mej 26x8 and have good throttle response as I have a hat cam video of this.
My DA-60/RE-2 would not even turn the Xoar 25B with a spool up that could be used in 3D
I have run a Mejzlik 24x10TH on both of them and the DA-60 spins it 200-300 more RPM, but the PTE gets there quicker.
I have never worked with the 40% class motors. I know in full scale, a 6 cylinder has better throttle response than a large 4. On a fuel miser plane like a Mooney, the 4 cylinder wins over a small 6.
There are volumetric and mechanical losses associated with each cylinder.